Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein
Hyeon-Jin Kim, Soo-Cheon Chae, Dae-Kwon Lee, Brett Chromy, Sam Sheol Lee, Yeong-Chul Park, William L. Klein, Grant A. Krafft, and Seong-Tshool Hong
The FASEB Journal (2003) Vol. 17,118-120

CONCLUSIONS:  Soluble oligomeric Aβ may be a missing link that can resolve an apparent contradiction in the amyloid cascade hypothesis, providing a possible explanation for the selective regional neurodegeneration that characterizes AD. Understanding the cellular mechanisms underlying a specific pathogenic process usually identifies viable molecular targets. Therefore, our observation of the selective neurotoxicity of soluble oligomeric Ab to neurons involved in cognitive function may provide a new opportunity for the development of an effective AD therapy as well as elucidating the pathological mechanism of AD.