Targeting small Aβ oligomers: the solution to an Alzheimer’s disease conundrum?
William L. Klein, Grant A. Krafft and Caleb E. Finch
Trends in Neurosciences Vol.24 No.4 April 2001

ABSTRACT: Amyloid β(Aβ) is a small self-aggregating peptide produced at low levels by normal brain metabolism. In Alzheimer’s disease (AD), self-aggregation of Ab becomes rampant, manifested most strikingly as the amyloid fibrils of senile plaques. Because fibrils can kill neurons in culture, it has been argued that fibrils initiate the neurodegenerative cascades of AD. An emerging and different view, however, is that fibrils are not the only toxic form of Aβ, and perhaps not the neurotoxin that is most relevant to AD: small oligomers and protofibrils also have potent neurological activity. Immuno-neutralization of soluble Ab-derived toxins might be the key to optimizing AD vaccines that are now on the horizon.